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Results for "MutY, C-terminal": 1 gene, 2 gene sets

Name

MUTYH Gene

mutY homolog

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]

MutY, C-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the MutY, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

muty Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term muty in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.