Harmonizome 3.0

Nanog homeobox

The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

NANOG neighbor homeobox-like

Nanog homeobox pseudogene 8

This gene represents a transcribed retrogene of the Nanog homeobox gene. The putative encoded protein may participate in reprogramming of cancer cells. In vitro studies using a recombinant protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to the Nanog protein. [provided by RefSeq, Sep 2017]

Nanog homeobox pseudogene 9

Nanog homeobox pseudogene 6

Nanog homeobox pseudogene 7

Nanog homeobox pseudogene 4

Nanog homeobox pseudogene 5

Nanog homeobox pseudogene 2

Nanog homeobox pseudogene 3

Nanog homeobox pseudogene 1

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; regulation of transcription by RNA polymerase II; and stem cell population maintenance. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

NANOG neighbor homeobox

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

Nanog homeobox pseudogene 10

Nanog homeobox pseudogene 11