Name

PTCPRN Gene

Papillary thyroid carcinoma with papillary renal neoplasia

MEN1 Gene

multiple endocrine neoplasia I

This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019]

CLLS2 Gene

Disrupted in B-cell neoplasia

CNC2 Gene

Carney complex type 2, multiple neoplasia and lentiginosis

CRNDE Gene

colorectal neoplasia differentially expressed (non-protein coding)

This gene is transcribed into multiple transcript variants, some of which may function as non-coding RNAs. One of the transcript variants encodes a putative short protein that is localized to the nucleus (PMID:25978564). Expression of this locus is increased in proliferating tissues, including certain tumors such as colorectal adenomas and adenocarcinomas. Transcription from this gene is negatively regulated by insulin and insulin-like growth factors, and may regulate the expression of genes involved in metabolism. [provided by RefSeq, May 2015]