Name

POU5F1 Gene

POU class 5 homeobox 1

This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

POU5F1B Gene

POU class 5 homeobox 1B

This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]

POU5F1P2 Gene

POU class 5 homeobox 1 pseudogene 2

POU5F1P3 Gene

POU class 5 homeobox 1 pseudogene 3

POU5F1P4 Gene

POU class 5 homeobox 1 pseudogene 4

POU5F1P6 Gene

POU class 5 homeobox 1 pseudogene 6

POU5F1P7 Gene

POU class 5 homeobox 1 pseudogene 7

POU5F1P5 Gene

POU class 5 homeobox 1 pseudogene 5