Harmonizome 3.0

ubiquitin carboxyl-terminal hydrolase 17-like protein

carboxyl ester lipase

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

histidine rich carboxyl terminus 1

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) pseudogene

ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like

carboxyl ester lipase pseudogene

ubiquitin carboxyl-terminal hydrolase L5

Enables cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Involved in several processes, including positive regulation of smoothened signaling pathway; protein deubiquitination; and regulation of primary metabolic process. Located in cytosol and nuclear lumen. [provided by Alliance of Genome Resources, Mar 2025]

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]

ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) pseudogene

putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23

ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like