ng>carboxypeptidaseng> N, polypeptide 2
Predicted to enable enzyme regulator activity. Predicted to be involved in protein stabilization. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Mar 2025]
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ng>carboxypeptidaseng> N, polypeptide 1
ng>Carboxypeptidaseng> N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from ng>carboxypeptidaseng> N deficiency. [provided by RefSeq, Jul 2008]
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ng>carboxypeptidaseng> X (M14 family), member 1
This gene likely encodes a member of the ng>carboxypeptidaseng> family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a ng>carboxypeptidaseng> domain, but the protein appears to lack residues necessary for ng>carboxypeptidaseng> activity.[provided by RefSeq, May 2010]
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ng>carboxypeptidaseng> X (M14 family), member 2
Predicted to enable metallong>carboxypeptidaseng> activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025]
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ng>carboxypeptidaseng> A1 (pancreatic)
This gene encodes a member of the ng>carboxypeptidaseng> A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]
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ng>carboxypeptidaseng>, vitellogenic-like
The protein encoded by this gene is a ng>carboxypeptidaseng> and bears strong sequence similarity to serine ng>carboxypeptidaseng>s. ng>Carboxypeptidaseng>s are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. [provided by RefSeq, Jan 2017]
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ng>carboxypeptidaseng> A2 (pancreatic)
Three different forms of human pancreatic prong>carboxypeptidaseng> A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic prong>carboxypeptidaseng> acts on aromatic C-terminal residues and is a secreted protein. [provided by RefSeq, Dec 2008]
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ng>carboxypeptidaseng> A3 (mast cell)
This gene encodes a member of the ng>carboxypeptidaseng> A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]
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ng>carboxypeptidaseng> A6
The gene encodes a member of the peptidase M14 family of metallong>carboxypeptidaseng>s. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which catalyzes the release of large hydrophobic C-terminal amino acids. This enzyme has functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Mutations in this gene may be linked to epilepsy and febrile seizures, and a translocation t(6;8)(q26;q13) involving this gene has been associated with Duane retraction syndrome. [provided by RefSeq, May 2016]
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ng>carboxypeptidaseng> A4
This gene is a member of the ng>carboxypeptidaseng> A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. ng>Carboxypeptidaseng>s are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]
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ng>carboxypeptidaseng> A5
ng>Carboxypeptidaseng>s have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of ng>carboxypeptidaseng>s, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active ng>carboxypeptidaseng> domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]
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ng>carboxypeptidaseng> M
The protein encoded by this gene is a membrane-bound arginine/lysine ng>carboxypeptidaseng>. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of ng>carboxypeptidaseng>s A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
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ng>carboxypeptidaseng> O
This gene is a member of the metallong>carboxypeptidaseng> gene family. [provided by RefSeq, Jan 2011]
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ng>carboxypeptidaseng> D
The metallong>carboxypeptidaseng> family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic ng>carboxypeptidaseng>-like and the regulatory B-type ng>carboxypeptidaseng> subfamilies. ng>Carboxypeptidaseng> D has been identified as a regulatory B-type ng>carboxypeptidaseng>. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
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ng>carboxypeptidaseng> E
This gene encodes a member of the M14 family of metallong>carboxypeptidaseng>s. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
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ng>carboxypeptidaseng> Z
This gene encodes a member of the metallong>carboxypeptidaseng> family. This enzyme displays ng>carboxypeptidaseng> activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallong>carboxypeptidaseng>s. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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ng>carboxypeptidaseng> Q
This gene encodes a metallopeptidase that belongs to the peptidase M28 family. The encoded protein may catalyze the cleavage of dipeptides with unsubstituted terminals into amino acids. [provided by RefSeq, Jul 2013]
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serine ng>carboxypeptidaseng> 1
Predicted to enable serine-type ng>carboxypeptidaseng> activity. Predicted to be involved in negative regulation of blood pressure and retinoic acid metabolic process. Predicted to act upstream of or within blood vessel diameter maintenance. Located in extracellular exosome. [provided by Alliance of Genome Resources, Mar 2025]
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ng>carboxypeptidaseng> B2 (plasma)
ng>Carboxypeptidaseng>s are enzymes that hydrolyze C-terminal peptide bonds. The ng>carboxypeptidaseng> family includes metallo-, serine, and cysteine ng>carboxypeptidaseng>s. According to their substrate specificity, these enzymes are referred to as ng>carboxypeptidaseng> A (cleaving aliphatic residues) or ng>carboxypeptidaseng> B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on ng>carboxypeptidaseng> B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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ng>carboxypeptidaseng> B1 (tissue)
Three different prong>carboxypeptidaseng>s A and two different prong>carboxypeptidaseng>s B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. ng>Carboxypeptidaseng> B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]
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microtubule associated tyrosine ng>carboxypeptidaseng> 2
Predicted to enable ng>carboxypeptidaseng> activity; metal ion binding activity; and metallopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Mar 2025]
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microtubule associated tyrosine ng>carboxypeptidaseng> 1
Enables tubulin-tyrosine ng>carboxypeptidaseng>. Predicted to be involved in brain development. Is active in microtubule. [provided by Alliance of Genome Resources, Mar 2025]
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