Harmonizome 3.0

H19, imprinted maternally expressed transcript (non-protein coding)

This gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. This gene is only expressed from the maternally-inherited chromosome, whereas IGF2 is only expressed from the paternally-inherited chromosome. The product of this gene is a long non-coding RNA which functions as a tumor suppressor. Mutations in this gene have been associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

maternally expressed 3 (non-protein coding)

This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]

maternally expressed 9 (non-protein coding)

maternally expressed 8 (non-protein coding)

This gene is located in a cluster of imprinted genes on chromosome 14q32.3. It encodes a a non-protein coding transcript that is preferentially expressed from the maternal allele in skeletal muscle, and appears to be coordinately regulated with other imprinted genes in this region. [provided by RefSeq, Oct 2010]

Diabetes mellitus, noninsulin-dependent

non-insulin-dependent diabetes mellitus (common, type 2) 2

Noninsulin-dependent diabetes mellitus 3

non-insulin-dependent diabetes mellitus (common, type 2) 1

insulin-dependent diabetes mellitus 18

insulin-dependent diabetes mellitus 15

insulin-dependent diabetes mellitus 13

insulin-dependent diabetes mellitus 11

Diabetes mellitus, insulin-dependent, 24

Diabetes mellitus, insulin-dependent, 23

insulin-dependent diabetes mellitus 17

insulin-dependent diabetes mellitus 16

insulin-dependent diabetes mellitus 14

Ras-related associated with diabetes

Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in T-tubule. Predicted to be active in plasma membrane. Implicated in type 2 diabetes mellitus. Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Mar 2025]

diabetes mellitus, transient neonatal

Transient neonatal diabetes mellitus is associated with overexpression of a region containing the PLAGL1 and HYMAI genes on chromosome 6q24. These genes are normally imprinted and expressed only from the paternal allele. Imprinting is regulated by differential methylation of a CpG island in this region. [provided by RefSeq, May 2015]

Diabetes mellitus, insulin-dependent, X-linked, susceptibility to

insulin-dependent diabetes mellitus 7

insulin-dependent diabetes mellitus 6

insulin-dependent diabetes mellitus 4

insulin-dependent diabetes mellitus 3

insulin-dependent diabetes mellitus 9

insulin-dependent diabetes mellitus 8