Harmonizome 3.0

ong>hemeong> oxygenase 1

ong>Hemeong> oxygenase, an essential enzyme in ong>hemeong> catabolism, cleaves ong>hemeong> to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. ong>Hemeong> oxygenase activity is induced by its substrate ong>hemeong> and by various nonong>hemeong> substances. ong>Hemeong> oxygenase occurs as 2 isozymes, an inducible ong>hemeong> oxygenase-1 and a constitutive ong>hemeong> oxygenase-2. HMOX1 and HMOX2 belong to the ong>hemeong> oxygenase family. [provided by RefSeq, Jul 2008]

ong>hemeong> oxygenase 2

ong>Hemeong> oxygenase, an essential enzyme in ong>hemeong> catabolism, cleaves ong>hemeong> to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. ong>Hemeong> oxygenase activity is induced by its substrate ong>hemeong> and by various nonong>hemeong> substances. ong>Hemeong> oxygenase occurs as 2 isozymes, an inducible ong>hemeong> oxygenase-1 and a constitutive ong>hemeong> oxygenase-2. HMOX1 and HMOX2 belong to the ong>hemeong> oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

COX10 ong>hemeong> A:farnesyltransferase cytochrome c oxidase assembly factor

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes ong>hemeong> A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the ong>hemeong> A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]

ong>hemeong> binding protein 2 pseudogene

ong>hemeong> binding protein 1

The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]

ong>hemeong> binding protein 2

The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]

solute carrier family 48 (ong>hemeong> transporter), member 1

Enables ong>hemeong> binding activity and ong>hemeong> transmembrane transporter activity. Involved in ong>hemeong> transport. Located in endosome membrane; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]