Harmonizome 3.0

katanin p80 subunit B-like 1

Predicted to enable microtubule binding activity. Involved in cytoplasmic microtubule organization and positive regulation of cytoskeleton organization. Located in several cellular components, including cleavage furrow; mitotic spindle pole; and nuclear lumen. Part of katanin complex. [provided by Alliance of Genome Resources, Mar 2025]

katanin p60 (ATPase containing) subunit A 1

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

katanin p60 subunit A-like 1

Enables identical protein binding activity and microtubule severing ATPase activity. Involved in microtubule severing. Located in cytoplasm; microtubule; and spindle pole. Part of katanin complex. [provided by Alliance of Genome Resources, Mar 2025]

katanin p60 subunit A-like 2

Predicted to enable ATP hydrolysis activity. Predicted to be involved in cytoplasmic microtubule organization. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Mar 2025]

katanin p80 (WD repeat containing) subunit B 1

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]

katanin p80 subunit B-like 1 pseudogene 5

katanin p80 subunit B-like 1 pseudogene 1

katanin p80 subunit B-like 1 pseudogene 2

katanin p80 subunit B-like 1 pseudogene 3

katanin p80 subunit B-like 1 pseudogene 4

katanin p80 subunit B-like 1 pseudogene 6

katanin interacting protein

This gene encodes a novel, evolutionarily conserved, ciliary protein. In human hTERT-RPE1 cells, the protein is found at the base of cilia, decorating the ciliary axoneme, and enriched at the ciliary tip. The protein binds to microtubules in vitro and regulates their stability when it is overexpressed. A null mutation in this gene has been associated with Joubert syndrome, a recessive disorder that is characterized by a distinctive mid-hindbrain and cerebellar malformation and is also often associated with wider ciliopathy symptoms. Consistently, in a serum-starvation ciliogenesis assay, human fibroblast cells derived from patients with the mutation display a reduced number of ciliated cells with abnormally long cilia. [provided by RefSeq, Feb 2016]