Harmonizome 3.0

Heart rate QTL 1

SWI5 recombination repair homolog (yeast) pseudogene

recombination signal binding protein for immunoglobulin kappa J region-like

This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

recombination signal binding protein for immunoglobulin kappa J region pseudogene

SWI5-dependent recombination repair 1

Enables nuclear receptor coactivator activity. Involved in cellular response to estrogen stimulus; double-strand break repair via homologous recombination; and positive regulation of DNA-templated transcription. Located in centrosome; nucleolus; and nucleoplasm. Part of Swi5-Sfr1 complex. [provided by Alliance of Genome Resources, Mar 2025]

REC8 meiotic recombination protein

This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

MRE11 meiotic recombination 11 homolog B (pseudogene)

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SWI5 recombination repair homolog (yeast)

Involved in cellular response to ionizing radiation and double-strand break repair via homologous recombination. Part of Swi5-Sfr1 complex. [provided by Alliance of Genome Resources, Mar 2025]

recombination signal binding protein for immunoglobulin kappa J region

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

REC114 meiotic recombination protein

The protein encoded by this gene is orthologous to the mouse meiotic recombination protein REC114, which is involved in DNA double-strand break formation during meiosis. The encoded protein is conserved in most eukaryotes and was first discovered and characterized in yeast. [provided by RefSeq, Feb 2017]

recombination activating gene 2

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]

recombination activating gene 1

The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008]

homologous recombination factor with OB-fold

Predicted to enable single-stranded DNA binding activity. Involved in DNA synthesis involved in DNA repair and interstrand cross-link repair. Located in site of DNA damage. [provided by Alliance of Genome Resources, Mar 2025]

FIGNL1 interacting regulator of recombination and mitosis

Enables protein kinase binding activity. Involved in several processes, including chromosome segregation; interstrand cross-link repair; and regulation of protein kinase activity. Located in several cellular components, including kinetochore; midbody; and spindle midzone. [provided by Alliance of Genome Resources, Mar 2025]

Allergic/atopic asthma related QTL 40

Allergic/atopic asthma related QTL 45

Blood pressure QTL 49

body mass index QTL 6

body mass index QTL 5

body mass index QTL 2

body mass index QTL 3

body mass index QTL 1

Creatinine clearance QTL

Blood pressure QTL 24

Blood pressure QTL 25

Blood pressure QTL 26

Blood pressure QTL 27

Blood pressure QTL 20

Blood pressure QTL 21

Blood pressure QTL 22

Blood pressure QTL 23

Blood pressure QTL 28

Blood pressure QTL 29

Body weight QTL 1

Body weight QTL 2

Body weight QTL 3

Body weight QTL 4

Body weight QTL 6

Body weight QTL 7

Body weight QTL 8

Body weight QTL 9

Cohen syndrome QTL 1

Fasting plasma glucose level QTL 4

Fasting plasma glucose level QTL 6

Fasting plasma glucose level QTL 1

Rheumatoid arthritis QTL 26

Body weight QTL 27

Body weight QTL 26

Body weight QTL 24

Body weight QTL 23

Body weight QTL 22

Body weight QTL 20

Body weight QTL 29

Body weight QTL 28

Chronic obstructive pulmonary disease QTL 14

Circulating adiponectin QTL on chromosome 5

Bone mineral density QTL 9

Bone mineral density QTL 6

Bone mineral density variation QTL 5

Body mass index QTL 15

Rheumatoid arthritis QTL 06

Rheumatoid arthritis QTL 07

Rheumatoid arthritis QTL 04

Rheumatoid arthritis QTL 01

Rheumatoid arthritis QTL 01

Rheumatoid arthritis QTL 02

Rheumatoid arthritis QTL 01

Rheumatoid arthritis QTL 08

Allergic/atopic asthma related QTL 18

Allergic/atopic asthma related QTL 13

Allergic/atopic asthma related QTL 15

Allergic/atopic asthma related QTL 14

Allergic/atopic asthma related QTL 16

Body fluid distribution QTL 1

Body fluid distribution QTL 3

Body fluid distribution QTL 4

Body fluid distribution QTL 5

Serum leptin concentration QTL 3

Serum leptin concentration QTL 2

Serum leptin concentration QTL 1

High density lipoprotein cholesterol level QTL 6

high density lipoprotein cholesterol level QTL 1

Allergic/atopic asthma related QTL 38

Allergic/atopic asthma related QTL 37

Chronic obstructive pulmonary disease QTL 3

Chronic obstructive pulmonary disease QTL 2

Chronic obstructive pulmonary disease QTL 1

Chronic obstructive pulmonary disease QTL 6

Chronic obstructive pulmonary disease QTL 5

Chronic obstructive pulmonary disease QTL 4

Chronic obstructive pulmonary disease QTL 8

Osteoarthritis QTL 10

Bone size QTL

C-reactive protein QTL

Blood pressure QTL 1

Blood pressure QTL 3

Blood pressure QTL 2

Blood pressure QTL 5

Blood pressure QTL 4

Blood pressure QTL 7

Blood pressure QTL 6

Blood pressure QTL 9

Blood pressure QTL 8

Osteoarthritis QTL 29

Specific language impairment QTL, 2

Specific language impairment QTL, 3

Specific language impairment QTL, 1

Body weight QTL 56

Body weight QTL 57

Body weight QTL 54

Body weight QTL 55

Body weight QTL 52

Body weight QTL 53

Body weight QTL 58

Body weight QTL 59

Alkaline phosphatase, plasma level of, QTL 2

Allergic/atopic asthma related QTL 48

Allergic/atopic asthma related QTL 49

Rheumatoid arthritis QTL 24

Lean body mass QTL 1

menopause, natural, age at, QTL

Cholesterol level QTL 2

Tuberculin skin test reactivity QTL

Rheumatoid arthritis QTL 21

Rheumatoid arthritis QTL 20

Rheumatoid arthritis QTL 23

Rheumatoid arthritis QTL 22

Rheumatoid arthritis QTL 25

Rheumatoid arthritis QTL 27

Rheumatoid arthritis QTL 29

Rheumatoid arthritis QTL 28

Allergic/atopic asthma related QTL 42

Allergic/atopic asthma related QTL 43

Allergic/atopic asthma related QTL 47

Allergic/atopic asthma related QTL 44

Body weight QTL 15

Body weight QTL 36

Body weight QTL 37

Thyroid-stimulating hormone level QTL 1

Cohen syndrome QTL 2

Body weight QTL 88

Osteoarthritis QTL 3

Chronic obstructive pulmonary disease QTL 17

Allergic/atopic asthma related QTL 9

Allergic/atopic asthma related QTL 8

Allergic/atopic asthma related QTL 7

Allergic/atopic asthma related QTL 6

Allergic/atopic asthma related QTL 1

Allergic/atopic asthma related QTL 3

Allergic/atopic asthma related QTL 2

Rheumatoid arthritis QTL 18

Rheumatoid arthritis QTL 19

Rheumatoid arthritis QTL 10

Rheumatoid arthritis QTL 11

Rheumatoid arthritis QTL 12

Rheumatoid arthritis QTL 13

Rheumatoid arthritis QTL 14

Rheumatoid arthritis QTL 15

Rheumatoid arthritis QTL 16

Rheumatoid arthritis QTL 17

Blood pressure QTL 51

Blood pressure QTL 50

Blood pressure QTL 53

Blood pressure QTL 52

Blood pressure QTL 55

Blood pressure QTL 54

Stature QTL 23

Stature QTL 20

Body weight QTL 35

Body weight QTL 30

Body weight QTL 33

Chronic obstructive pulmonary disease QTL 7

Chronic obstructive pulmonary disease QTL 9

Allergic/Atopic asthma related QTL 29

Allergic/atopic asthma related QTL 24

Allergic/atopic asthma related QTL 25

Allergic/atopic asthma related QTL 27

Allergic/atopic asthma related QTL 20

Allergic/atopic asthma related QTL 21

Allergic/atopic asthma related QTL 22

Body weight QTL 5

Osteoarthritis QTL 26

Osteoarthritis QTL 25

Osteoarthritis QTL 27

Osteoarthritis QTL 24

Osteoarthritis QTL 22

Osteoarthritis QTL 23

Osteoarthritis QTL 20

Osteoarthritis QTL 21

Osteoarthritis QTL 28

Osteoarthritis QTL 29

Body weight QTL 25

Allergic/Atopic asthma related QTL 41

Allergic/atopic asthma related QTL 46

Stature QTL 17

Urinary albumin excretion QTL 1

Urinary albumin excretion QTL 2

Stature QTL 15

Stature QTL 13

Bone mineral density QTL 10

Bone mineral density QTL 11

Bone mineral density QTL 13

Bone mineral density QTL 14

Allergic/atopic asthma related QTL 25

Body weight QTL 69

Body weight QTL 68

Body weight QTL 63

Body weight QTL 62

Body weight QTL 61

Body weight QTL 60

Body weight QTL 67

Body weight QTL 66

Body weight QTL 65

Body weight QTL 64

Bone size QTL

Body weight QTL 11

Circulating adiponectin QTL on chromosome 14

Allergic/atopic asthma related QTL 5

Allergic/atopic asthma related QTL 54

Allergic/Atopic asthma related QTL 56

Allergic/atopic asthma related QTL 51

Allergic/atopic asthma related QTL 53

Allergic/atopic asthma related QTL 52

Bone mineral density variation QTL 4

Allergic/atopic asthma related QTL 4

Rheumatoid arthritis QTL 09

Body fluid distribution QTL 2

Blood pressure QTL 37

Blood pressure QTL 36

Blood pressure QTL 35

Blood pressure QTL 34

Blood pressure QTL 33

Blood pressure QTL 32

Blood pressure QTL 31

Blood pressure QTL 30

Blood pressure QTL 39

Blood pressure QTL 38

Blood pressure QTL 18

Blood pressure QTL 14

Allergic/atopic asthma related QTL 11

Allergic/atopic asthma related QTL 12

Allergic/atopic asthma related QTL 17

Rheumatoid arthritis QTL 30

Rheumatoid arthritis QTL 31

Fetal hemoglobin QTL on chromosome 8

Body weight QTL 12

Body weight QTL 13

Body weight QTL 10

Body weight QTL 16

Body weight QTL 17

Body weight QTL 14

Body weight QTL 18

Body weight QTL 19

Allergic/atopic asthma related QTL 19

Allergic/atopic asthma related QTL 10

Stature QTL 16

Stature QTL 14

Stature QTL 12

Stature QTL 10

Musical aptitude QTL 1

Stature QTL 11

Stature QTL 18

Stature QTL 19

Body weight QTL 34

Body weight QTL 31

Body weight QTL 32

Allergic/atopic asthma related QTL 50

Blood pressure QTL 46

Blood pressure QTL 47

Blood pressure QTL 45

Blood pressure QTL 48

Birth weight QTL 2

Chronic obstructive pulmonary disease QTL 13

Chronic obstructive pulmonary disease QTL 12

Chronic obstructive pulmonary disease QTL 11

Chronic obstructive pulmonary disease QTL 10

Chronic obstructive pulmonary disease QTL 16

Chronic obstructive pulmonary disease QTL 15

Chronic obstructive pulmonary disease QTL 19

Chronic obstructive pulmonary disease QTL 18

Osteoarthritis QTL 7

Osteoarthritis QTL 6

Osteoarthritis QTL 5

Osteoarthritis QTL 4

Osteoarthritis QTL 2

Osteoarthritis QTL 1

Osteoarthritis QTL 9

Osteoarthritis QTL 8

Allergic/atopic asthma related QTL 39

Allergic/atopic asthma related QTL 36

Allergic/atopic asthma related QTL 35

Allergic/atopic asthma related QTL 34

Allergic/atopic asthma related QTL 33

Allergic/Atopic asthma related QTL 32

Allergic/atopic asthma related QTL 31

Allergic/atopic asthma related QTL 30

Allergic/atopic asthma related QTL 5

Vitamin B6 plasma level QTL 1

Stature QTL 24

Stature QTL 21

Menarche, age at, QTL

High density lipoprotein cholesterol level QTL 4

High density lipoprotein cholesterol level QTL 5

High density lipoprotein cholesterol level QTL on chromosome 8

Allergic/Atopic asthma related QTL 28

Allergic/atopic asthma related QTL 23

Stature QTL 22

Blood pressure QTL 19

Blood pressure QTL 15

Blood pressure QTL 17

Blood pressure QTL 16

Blood pressure QTL 11

Blood pressure QTL 10

Blood pressure QTL 13

Blood pressure QTL 12

Osteoarthritis QTL 19

Osteoarthritis QTL 18

Osteoarthritis QTL 13

Osteoarthritis QTL 12

Osteoarthritis QTL 11

Osteoarthritis QTL 17

Osteoarthritis QTL 16

Osteoarthritis QTL 15

Osteoarthritis QTL 14

Chronic obstructive pulmonary disease QTL 28

Chronic obstructive pulmonary disease QTL 29

Chronic obstructive pulmonary disease QTL 22

Chronic obstructive pulmonary disease QTL 23

Chronic obstructive pulmonary disease QTL 20

Chronic obstructive pulmonary disease QTL 21

Chronic obstructive pulmonary disease QTL 26

Chronic obstructive pulmonary disease QTL 27

Chronic obstructive pulmonary disease QTL 24

Chronic obstructive pulmonary disease QTL 25

Body weight QTL 70

Body weight QTL 71

Body weight QTL 72

Sex hormone-binding blobulin circulating level QTL 1