Harmonizome 3.0

Immune response to synthetic polypeptide--IRGAT

T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3

This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]

Immune suppression to streptococcal antigen

immune response to synthetic polypeptides 1

immune response to synthetic polypeptides 2

transcriptional and immune response regulator

This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

cytochrome c, somatic pseudogene 38

cytochrome c, somatic pseudogene 39

cytochrome c, somatic pseudogene 34

cytochrome c, somatic pseudogene 35

cytochrome c, somatic pseudogene 30

cytochrome c, somatic pseudogene 32

cytochrome c, somatic pseudogene 49

cytochrome c, somatic pseudogene 48

cytochrome c, somatic pseudogene 46

cytochrome c, somatic pseudogene 41

cytochrome c, somatic pseudogene 40

cytochrome c, somatic pseudogene 43

cytochrome c, somatic pseudogene 42

cytochrome c, somatic pseudogene 45

cytochrome c, somatic pseudogene 44

cytochrome c, somatic pseudogene 16

cytochrome c, somatic pseudogene 17

cytochrome c, somatic pseudogene 14

cytochrome c, somatic pseudogene 12

cytochrome c, somatic pseudogene 10

cytochrome c, somatic pseudogene 11

cytochrome c, somatic pseudogene 18

cytochrome c, somatic pseudogene 19

cytochrome c, somatic pseudogene 33

cytochrome c, somatic pseudogene 29

cytochrome c, somatic pseudogene 28

cytochrome c, somatic pseudogene 27

cytochrome c, somatic pseudogene 26

cytochrome c, somatic pseudogene 24

cytochrome c, somatic pseudogene 23

cytochrome c, somatic pseudogene 22

cytochrome c, somatic pseudogene 20

cytochrome c, somatic pseudogene 25

cytochrome c, somatic pseudogene 8

cytochrome c, somatic pseudogene 4

cytochrome c, somatic pseudogene 5

cytochrome c, somatic pseudogene 6

cytochrome c, somatic pseudogene 7

cytochrome c, somatic pseudogene 1

cytochrome c, somatic pseudogene 2

cytochrome c, somatic pseudogene 3

cytochrome c, somatic pseudogene 52

cytochrome c, somatic pseudogene 53

cytochrome c, somatic pseudogene 51

cytochrome c, somatic pseudogene 55

cytochrome c, somatic

This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]