Harmonizome 3.0

glutamyl aminopeptidase (aminopeptidase A)

The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term enpep in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ENPEP from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the ENPEP gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From HuBMAP Azimuth Cell Type Annotations

genes associated with the Human - Motor Cortex - Cluster - THEMIS+ ENPEP+ Layer 3 glutamatergic neuron cell type from the HuBMAP Azimuth Cell Type Annotations dataset.

From HuBMAP ASCT+B Annotations

biomarker genes for the Brain_CT2_Exc L3 THEMIS ENPEP cell type from the HuBMAP ASCT+B dataset.

From HuBMAP ASCT+B Augmented with RNA-seq Coexpression

biomarker genes for the Brain_CT2_Exc L3 THEMIS ENPEP cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.