Harmonizome 3.0

TRK-fused gene pseudogene

TRK-fused gene

There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

suppressor of fused homolog (Drosophila)

The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

asphixiating thoracic dystrophy (chondroectodermal dysplasia-like syndrome)

Aortic aneurysm, familial thoracic 2

Aortic aneurysm, familial thoracic 1