Harmonizome 3.0

TBC1 domain family, member 9B (with GRAM domain)

Predicted to enable GTPase activator activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

GRAM domain containing 4 pseudogene 1

GRAM domain containing 4 pseudogene 3

GRAM domain containing 4 pseudogene 2

GRAM domain containing 4 pseudogene 5

GRAM domain containing 4 pseudogene 7

GRAM domain containing 4 pseudogene 8

TBC1 domain family, member 8B (with GRAM domain)

This gene encodes a protein with a TBC (Tre-2/Bub2/CDC16) domain. Some mammalian proteins with this domain have been shown to function as Rab-GAPs by binding to specific Rab proteins and affecting their GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GRAM domain containing 4 pseudogene 6

TBC1 domain family, member 8 (with GRAM domain)

Predicted to enable GTPase activator activity. Predicted to be involved in blood circulation and positive regulation of cell population proliferation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

TBC1 domain family, member 9 (with GRAM domain)

Predicted to enable GTPase activator activity. [provided by Alliance of Genome Resources, Mar 2025]

GRAM domain containing 3

Enables identical protein binding activity. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Mar 2025]

GRAM domain containing 2

Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in endoplasmic reticulum-plasma membrane tethering and regulation of store-operated calcium entry. Located in endoplasmic reticulum membrane; organelle membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

GRAM domain containing 4

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]

GRAM domain containing 1C

Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol and intracellular sterol transport. Predicted to be located in endoplasmic reticulum; membrane; and organelle membrane contact site. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

GRAM domain containing 1B

Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

GRAM domain containing 1A

Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol and intracellular sterol transport. Located in several cellular components, including cytosol; endoplasmic reticulum membrane; and organelle membrane contact site. [provided by Alliance of Genome Resources, Mar 2025]

GRAM domain containing 2B

Enables identical protein binding activity. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Mar 2025]

GRAM domain containing 2A

Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in endoplasmic reticulum-plasma membrane tethering and regulation of store-operated calcium entry. Located in endoplasmic reticulum membrane; organelle membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]