Harmonizome 3.0

dickkopf WNT signaling pathway inhibitor 1

This gene encodes a member ong>ofong> the dickkopf family ong>ofong> proteins. Members ong>ofong> this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression ong>ofong> this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]

WNT inhibitory factor 1

The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]

dickkopf WNT signaling pathway inhibitor 4

This gene encodes a protein that is a member ong>ofong> the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity ong>ofong> this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]

dickkopf WNT signaling pathway inhibitor 3

This gene encodes a protein that is a member ong>ofong> the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression ong>ofong> this gene is decreased in a variety ong>ofong> cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

dickkopf WNT signaling pathway inhibitor 2

This gene encodes a protein that is a member ong>ofong> the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist ong>ofong> Wnt/beta-catenin signaling, depending on the cellular context and the presence ong>ofong> the co-factor kremen 2. Activity ong>ofong> this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

wntless Wnt ligand secretion mediator

Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation ong>ofong> cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. Implicated in Zaki syndrome. [provided by Alliance ong>ofong> Genome Resources, Mar 2025]

WNT signaling pathway activating non-coding RNA