Harmonizome 3.0

MAP/microtubule affinity-regulating kinase 4

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

MAP/microtubule affinity-regulating kinase 1

Enables several functions, including ATP binding activity; magnesium ion binding activity; and phospholipid binding activity. Involved in intracellular signal transduction; negative regulation of epithelial to mesenchymal transition; and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

MAP/microtubule affinity-regulating kinase 2

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

MAP/microtubule affinity-regulating kinase 3

The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

MAP kinase interacting serine/threonine kinase 2

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

MAP kinase interacting serine/threonine kinase 1

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

MAP/microtubule affinity-regulating kinase 2 pseudogene

non-protein coding RNA, associated with MAP kinase pathway and growth arrest

MAP/microtubule affinity-regulating kinase 1 pseudogene

MAP/microtubule affinity-regulating kinase 2 pseudogene 12

MAP/microtubule affinity-regulating kinase 2 pseudogene 8

MAP/microtubule affinity-regulating kinase 2 pseudogene 9

MAP/microtubule affinity-regulating kinase 2 pseudogene 4

MAP/microtubule affinity-regulating kinase 2 pseudogene 5

MAP/microtubule affinity-regulating kinase 2 pseudogene 6

MAP/microtubule affinity-regulating kinase 2 pseudogene 7

MAP/microtubule affinity-regulating kinase 2 pseudogene 1

MAP/microtubule affinity-regulating kinase 2 pseudogene 2

MAP/microtubule affinity-regulating kinase 2 pseudogene 3

MAP kinase interacting serine/threonine kinase 2 pseudogene 1

MAP/microtubule affinity-regulating kinase 2 pseudogene

MAP/microtubule affinity-regulating kinase 4 pseudogene

MAP/microtubule affinity-regulating kinase 2 pseudogene

MAP/microtubule affinity-regulating kinase 4 pseudogene

MAP-kinase activating death domain

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

MAP/microtubule affinity-regulating kinase 2 pseudogene 16

MAP/microtubule affinity-regulating kinase 2 pseudogene 17

MAP/microtubule affinity-regulating kinase 2 pseudogene 14

MAP/microtubule affinity-regulating kinase 2 pseudogene 15

MAP/microtubule affinity-regulating kinase 2 pseudogene 13

MAP/microtubule affinity-regulating kinase 2 pseudogene 10

MAP/microtubule affinity-regulating kinase 2 pseudogene 11

MAP/microtubule affinity-regulating kinase 3 pseudogene 1

MAP/microtubule affinity-regulating kinase 3 pseudogene 3

MAP/microtubule affinity-regulating kinase 3 pseudogene 2

MAP/microtubule affinity-regulating kinase 2 pseudogene

MAP/microtubule affinity-regulating kinase 2 pseudogene