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Results for "MutL, C-terminal, dimerisation": 2 genes, 25 gene sets

Name

MLH3 Gene

mutL homolog 3

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

MLH1 Gene

mutL homolog 1

The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]

MutL, C-terminal, dimerisation Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the MutL, C-terminal, dimerisation protein domain from the InterPro Predicted Protein Domain Annotations dataset.

MutL-beta complex Gene Set

From CORUM Protein Complexes

proteins in the MutL-beta complex protein complex from the CORUM Protein Complexes dataset.

MutL-alpha complex Gene Set

From CORUM Protein Complexes

proteins in the MutL-alpha complex protein complex from the CORUM Protein Complexes dataset.

PCNA-MutS-alpha-MutL-alpha-DNA complex Gene Set

From CORUM Protein Complexes

proteins in the PCNA-MutS-alpha-MutL-alpha-DNA complex protein complex from the CORUM Protein Complexes dataset.

mutl Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mutl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

dimerisation Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dimerisation in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Transferrin receptor-like, dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transferrin receptor-like, dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Centromere protein CENP-B, dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Centromere protein CENP-B, dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Hepatocyte nuclear factor 1, dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Hepatocyte nuclear factor 1, dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Dicer dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Dicer dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Moybdenum cofactor oxidoreductase, dimerisation Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Moybdenum cofactor oxidoreductase, dimerisation protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Translation elongation factor EFTs/EF1B, dimerisation Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Translation elongation factor EFTs/EF1B, dimerisation protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

SKP1 component, dimerisation Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SKP1 component, dimerisation protein domain from the InterPro Predicted Protein Domain Annotations dataset.

RING-type zinc-finger, LisH dimerisation motif Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RING-type zinc-finger, LisH dimerisation motif protein domain from the InterPro Predicted Protein Domain Annotations dataset.

UDP-glucose/GDP-mannose dehydrogenase, dimerisation Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the UDP-glucose/GDP-mannose dehydrogenase, dimerisation protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Pyrroline-5-carboxylate reductase, dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Pyrroline-5-carboxylate reductase, dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Signal transduction histidine kinase EnvZ-like, dimerisation/phosphoacceptor domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Signal transduction histidine kinase EnvZ-like, dimerisation/phosphoacceptor domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

FAD/NAD-linked reductase, dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the FAD/NAD-linked reductase, dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Telomere repeat-binding factor, dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Telomere repeat-binding factor, dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidase M20, dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidase M20, dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

USP8 dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the USP8 dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

DNA-directed RNA polymerase, RBP11-like dimerisation domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the DNA-directed RNA polymerase, RBP11-like dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.