Harmonizome 3.0

phosphoribosyl pyrophosphate amidotransferase pseudogene 2

phosphoribosyl pyrophosphate amidotransferase

The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]

phosphoribosyl pyrophosphate synthetase 1 pseudogene 2

phosphoribosyl pyrophosphate synthetase 2 pseudogene

phosphoribosyl pyrophosphate synthetase 1 pseudogene 1

phosphoribosyl pyrophosphate synthetase 2

This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

phosphoribosyl pyrophosphate synthetase 1

This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

phosphoribosyl pyrophosphate synthetase 2 pseudogene

phosphoribosyl pyrophosphate synthetase 2 pseudogene

phosphoribosyl transferase domain containing 1

Enables protein homodimerization activity. Predicted to be involved in purine ribonucleoside salvage. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Mar 2025]

phosphoribosyl pyrophosphate synthetase 1-like 1

This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon. [provided by RefSeq, Jul 2008]

phosphoribosyl pyrophosphate amidotransferase pseudogene

phosphoribosyl pyrophosphate amidotransferase pseudogene 1

phosphoribosyl pyrophosphate synthetase-associated protein 1

Enables identical protein binding activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

phosphoribosyl pyrophosphate synthetase-associated protein 2

This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

From HMDB Metabolites of Enzymes

interacting proteins for the Phosphoribosyl-ATP metabolite from the curated HMDB Metabolites of Enzymes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term phosphoribosyl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the 5'-Phosphoribosyl-N-formylglycinamide metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Phosphoribosyl pyrophosphate metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the Phosphoribosyl formamidocarboxamide metabolite from the curated HMDB Metabolites of Enzymes dataset.

From HMDB Metabolites of Enzymes

interacting proteins for the 5'-phosphoribosyl-a-N-formylglycineamidine metabolite from the curated HMDB Metabolites of Enzymes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Hypoxanthine phosphoribosyl transferase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Nicotinamide phosphoribosyl transferase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphoribosyl pyrophosphate synthetase, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenine phosphoribosyl transferase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Quinolinate phosphoribosyl transferase, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Orotate phosphoribosyl transferase domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Quinolinate phosphoribosyl transferase, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MW Enzyme Metabolite Associations

interacting proteins for 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole metabolite from the MW Gene Metabolite Associations dataset.

From MW Enzyme Metabolite Associations

interacting proteins for Phosphoribosyl pyrophosphate metabolite from the MW Gene Metabolite Associations dataset.

From MW Enzyme Metabolite Associations

interacting proteins for 5'-Phosphoribosyl-N-formylglycinamide metabolite from the MW Gene Metabolite Associations dataset.