Harmonizome 3.0

recombination signal binding protein for immunoglobulin kappa J region

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

RBPJ pseudogene 1

RBPJ pseudogene 2

RBPJ pseudogene 4

RBPJ pseudogene 5

RBPJ pseudogene 6

RBPJ pseudogene 7

corepressor interacting with RBPJ, 1 pseudogene 1

corepressor interacting with RBPJ, 1 pseudogene 2

RBPJ pseudogene 3

corepressor interacting with RBPJ, 1

Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in centrosome and nuclear speck. Part of protein-containing complex. [provided by Alliance of Genome Resources, Mar 2025]

RBPJ interacting and tubulin associated 1

Enables tubulin binding activity. Involved in negative regulation of Notch signaling pathway and nuclear export. Located in centrosome; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

corepressor of RBPJ and splicing regulator

Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in centrosome and nuclear speck. Part of protein-containing complex. [provided by Alliance of Genome Resources, Mar 2025]