Harmonizome 3.0

ret proto-oncogene

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]

ret finger protein-like 4A-like 1

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 4B

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; negative regulation of viral entry into host cell; and negative regulation of viral transcription. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 4A

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be located in female germ cell nucleus. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 4A

ret finger protein-like 2 pseudogene

ret finger protein-like 1

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of G2/M transition of mitotic cell cycle; negative regulation of cell division; and positive regulation of proteolysis. Located in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 4A pseudogene 1

ret finger protein-like 4A pseudogene 5

ret finger protein-like 4A pseudogene 4

ret finger protein-like 4A pseudogene 6

ret finger protein-like 3

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be located in nucleus. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 2

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

ret finger protein-like 3 pseudogene

ret finger protein-like 4A pseudogene 2

ret finger protein-like 4A pseudogene 7