Harmonizome 3.0

suppression of tumorigenicity 5

This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]

From Pathway Commons Protein-Protein Interactions

interacting proteins for ST5 from the Pathway Commons Protein-Protein Interactions dataset.

From GeneSigDB Published Gene Signatures

genes in signature reported in the publication with PubMedID 20436685-ST5-1 from the GeneSigDB Published Gene Signatures dataset.

From GeneSigDB Published Gene Signatures

genes in signature reported in the publication with PubMedID 20436685-ST5-2 from the GeneSigDB Published Gene Signatures dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC12436147-41380_2025_3032_MOESM1_ESM.xlsx-ST5-Supplementary_Table5_Brain_cortex_eQTLs_that_were_selected_as_instruments_for_the_MR_analyses_METABRAIN_NR3C2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC12751804-12916_2025_4527_MOESM1_ESM.xlsx-ST5-Supplementary_Table_5_MR_and_colocalization_results_shown_together_NR3C2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.