Results for "Thiopurine S methyltranferase deficiency": 5 genes

Name

TPMTP1 Gene

<strong>thiopurinestrong> S-methyltransferase pseudogene 1

TPMTP3 Gene

<strong>thiopurinestrong> S-methyltransferase pseudogene 3

TPMTP2 Gene

<strong>thiopurinestrong> S-methyltransferase pseudogene 2

TPMTP4 Gene

<strong>thiopurinestrong> S-methyltransferase pseudogene 4

TPMT Gene

<strong>thiopurinestrong> S-methyltransferase

This gene encodes the enzyme that metabolizes <strong>thiopurinestrong> drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. <strong>Thiopurinestrong> drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing <strong>thiopurinestrong> S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]