Harmonizome 3.0

sperm acrosome associated 5B

Predicted to enable lysozyme activity. Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in extracellular region. Predicted to be active in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Mar 2025]

sperm acrosome associated 6, pseudogene

Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in acrosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

sperm acrosome associated 4

Involved in binding activity of sperm to zona pellucida. Located in inner acrosomal membrane and outer acrosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

sperm acrosome associated 5

Predicted to enable lysozyme activity. Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in extracellular region. Predicted to be active in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Mar 2025]

sperm acrosome associated 7

Predicted to act upstream of or within negative regulation of cell adhesion and single fertilization. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Mar 2025]

sperm acrosome associated 1

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]

sperm acrosome associated 3

The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

equatorin, sperm acrosome associated

Predicted to be involved in acrosomal vesicle exocytosis; endocytosis; and fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to act upstream of or within establishment of localization in cell. Predicted to be located in early endosome and nucleus. Predicted to be active in inner acrosomal membrane; outer acrosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

sperm acrosome associated 9

Enables microtubule binding activity. Involved in axoneme assembly. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Mar 2025]

sperm acrosome associated 6

Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in acrosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]

sperm acrosome developmental regulator

Involved in spermatid development. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Mar 2025]