Harmonizome 3.0

long intergenic non-protein coding RNA 907

microRNA 489

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

RNA, 5S ribosomal pseudogene 489

long intergenic non-protein coding RNA 489

melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489

Hypertension, essential, susceptibility to, 3

Hypertension, essential, susceptibility to, 5

Hypertension, essential, susceptibility to, 4

Hypertension, essential, susceptibility to, 7

Hypertension, essential, susceptibility to, 6

hypertension, essential, susceptibility to, 8

pregnancy-induced hypertension syndrome-related protein

hypertension with brachydactyly

Hypertension, essential, susceptibility to, 1

Hypertension, essential, susceptibility to, 2

Renal failure, progressive, with hypertension

Pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis, susceptibility to

primary pulmonary hypertension 2