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Results for "march1": 1 gene, 2 gene sets

Name

MARCH1 Gene

membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase

MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]

march1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term march1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MARCH1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MARCH1 from the Pathway Commons Protein-Protein Interactions dataset.