triphosphatase activity

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Results for "triphosphatase activity": 13 genes

Name
LOC101059986 Gene cancer-related nucleoside-triphosphatase* pseudogene*
THTPA Gene thiamine triphosphatase This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
DUT Gene deoxyuridine triphosphatase This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
DUTP2 Gene deoxyuridine triphosphatase* pseudogene 2*
DUTP3 Gene deoxyuridine triphosphatase* pseudogene 3*
DUTP1 Gene deoxyuridine triphosphatase* pseudogene 1*
DUTP6 Gene deoxyuridine triphosphatase* pseudogene 6*
DUTP7 Gene deoxyuridine triphosphatase* pseudogene 7*
DUTP4 Gene deoxyuridine triphosphatase* pseudogene 4*
DUTP5 Gene deoxyuridine triphosphatase* pseudogene 5*
DUTP8 Gene deoxyuridine triphosphatase* pseudogene 8*
ITPA Gene inosine triphosphatase* (nucleoside triphosphate pyrophosphatase)* This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
NTPCR Gene nucleoside-triphosphatase, cancer-related The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]