Harmonizome 3.0

von Willebrand factor

This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]

Modifier of von Willebrand factor

von Willebrand factor A domain containing 8

Predicted to enable ATP hydrolysis activity. Located in mitochondrion and peroxisome. [provided by Alliance of Genome Resources, Mar 2025]

von Willebrand factor A domain containing 7

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025]

von Willebrand factor A domain containing 2

This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013]

von Willebrand factor A domain containing 1

VWA1 belongs to the von Willebrand factor (VWF; MIM 613160) A (VWFA) domain superfamily of extracellular matrix proteins and appears to play a role in cartilage structure and function (Fitzgerald et al., 2002 [PubMed 12062410]).[supplied by OMIM, Nov 2010]

von Willebrand factor A domain containing 3B

This gene encodes an intracellular protein that contains a von Willebrand factor type A domain. Intracellular proteins with VWA domains are thought to function in transcription, DNA repair, ribosomal and membrane transport and the proteasome. Mutations in this gene are associated with Spinocerebellar ataxia, autosomal recessive 22. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2017]

von Willebrand factor A domain containing 3A

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025]

von Willebrand factor D and EGF domains

Predicted to enable signaling receptor binding activity. Predicted to be active in cell surface and extracellular region. [provided by Alliance of Genome Resources, Mar 2025]

von Willebrand factor A domain containing 5B2 pseudogene

von Willebrand factor C domain containing 2

This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009]

von Willebrand factor C domain containing protein 2-like

Predicted to be involved in negative regulation of BMP signaling pathway. Predicted to act upstream of or within positive regulation of neuron differentiation. Predicted to be located in extracellular region and synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Mar 2025]

von Willebrand factor A domain containing 5B2

von Willebrand factor A domain containing 5B1

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025]

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

Enables integrin binding activity. Involved in negative regulation of vasoconstriction and positive regulation of platelet activation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Mar 2025]

von Willebrand factor pseudogene 1

von Willebrand factor C and EGF domains

Predicted to enable calcium ion binding activity. Predicted to be involved in cellular response to virus. Located in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

von Willebrand factor A domain containing 9

Predicted to be involved in snRNA 3'-end processing. Located in cytoplasm. Part of integrator complex. Is active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

von Willebrand factor A domain containing 5A

Located in nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

von Willebrand factor A domain-containing protein 3A