TAMOXIFEN report

Categorized using metadata field disease

All reports

Gene signatures

Signatures (66) and Custom Report Builder
Title Organism Platform
1 Tamoxifen-resistant breast cancer cell line MCF7 subclones Homo sapiens Homo sapiens
2 Tamoxifen-resistant breast cancer cell line MCF7 subclones Homo sapiens Homo sapiens
3 Tamoxifen-resistant breast cancer cell line MCF7 subclones Homo sapiens Homo sapiens
4 Estrogen receptor alpha/beta heterodimer action in response to estrogen and tamoxifen Homo sapiens Homo sapiens
5 Estrogen receptor alpha/beta heterodimer action in response to estrogen and tamoxifen Homo sapiens Homo sapiens
6 Estrogen receptor alpha/beta heterodimer action in response to estrogen and tamoxifen Homo sapiens Homo sapiens
7 Transgenic model of selective ATF6 activation: heart Mus musculus Mus musculus
8 Transgenic model of selective ATF6 activation: heart Mus musculus Mus musculus
9 Tamoxifen-resistant breast cancer cell line MCF7 subclones Homo sapiens Homo sapiens
10 Tamoxifen-resistant breast cancer cell line MCF7 subclones Homo sapiens Homo sapiens
11 Proteasome inhibitor Bortezomib effect on MCF7 breast cancer cells Homo sapiens Homo sapiens
12 Transgenic model of selective ATF6 activation: heart Mus musculus Mus musculus
13 Transgenic model of selective ATF6 activation: heart Mus musculus Mus musculus
14 Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells Homo sapiens Homo sapiens
15 Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells Homo sapiens Homo sapiens
16 Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells Homo sapiens Homo sapiens
17 Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells Homo sapiens Homo sapiens
18 Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells Homo sapiens Homo sapiens
19 Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells Homo sapiens Homo sapiens
20 Embryonic stem cell response to STAT3 overexpression in vitro (MG-U74A) Mus musculus Mus musculus
21 Expression data from PKM1 or PKM2 expressing mouse embryonic fibroblasts. Mus musculus Mus musculus
22 Gene expression data from type II pneumocytes from adult mice with and without Trf2 Mus musculus Mus musculus
23 HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance Homo sapiens Homo sapiens
24 Knock out of NOTCH1-bound MYC enhancer (N-Me) Mus musculus Mus musculus
25 MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM Mus musculus Mus musculus
26 Expression data from embryonic stem cells differentiation Mus musculus Mus musculus
27 Expression data from embryonic stem cells differentiation Mus musculus Mus musculus
28 Expression data from embryonic stem cells differentiation Mus musculus Mus musculus
29 Expression data from embryonic stem cells differentiation Mus musculus Mus musculus
30 Expression data from embryonic stem cells differentiation Mus musculus Mus musculus
31 Calcineurin-dependent transcriptome in ICN1 (activated NOTCH1)-induced T cell acute lymphoblastic leukemia (T-ALL) Mus musculus Mus musculus
32 Transgenic model of selective ATF6 activation: heart Mus musculus Mus musculus
33 Transgenic model of selective ATF6 activation: heart Mus musculus Mus musculus
34 Genes regulated by estrogen and 4-hydroxytamoxifen in MCF-7:PF cells Homo sapiens Homo sapiens
35 Expression data from chemically-induced skin papillomas (benign tumours) Mus musculus Mus musculus
36 Expression data from adult lungs isolated from TMEM100-deficient mice Mus musculus Mus musculus
37 Effect of genetic Zfx deletion on gene expression in Notch induced T-ALL Mus musculus Mus musculus
38 Identification of Sox9-Regulated Pathways During the Secondary Transition Stage of Pancreas Development Mus musculus Mus musculus
39 Murine forestomach epithelial sheets: Controls vs. Sox2 overexpression mutants Mus musculus Mus musculus
40 Tamoxifen effect on SRC-1-deficient endocrine-resistant breast cancer cell line LY2 Homo sapiens Homo sapiens
41 Expression data from MCF7 tumor xenografts treated with either single agent BMS754807, or Tamoxifen or Letrozole alone; or Tamoxifen or Letrozole in combination with BMS754807 for 28 days Homo sapiens Homo sapiens
42 mRNA expression data from mice infected with H. pylori treated with estradiol, tamoxifen, or placebo Mus musculus Mus musculus
43 Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells Homo sapiens Homo sapiens
44 Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells Homo sapiens Homo sapiens
45 Tamoxifen-resistant breast cancer cell line MCF7 subclones Homo sapiens Homo sapiens
46 Tamoxifen-resistant breast cancer cell line MCF7 subclones Homo sapiens Homo sapiens
47 Expression profiling in control and YY1 knockout mouse intestinal crypt epithelia Mus musculus Mus musculus
48 Heart tissue from Nelf-b CreER mice Mus musculus Mus musculus
49 Expression data during plantaris muscle hypertrophy with/without satellite cells induced by synergist ablation in young adult Pax7-DTA mice Mus musculus Mus musculus
50 Effect of genetic Zfx deletion on gene expression in c-Kit + MLL-AF9 AML cells Mus musculus Mus musculus
51 Effect of genetic Zfx deletion on gene expression in c-Kit + MLL-AF9 AML cells Mus musculus Mus musculus
52 Estrogen receptor dynamics in diverse patient-derived luminal breast cancer xenografts Homo sapiens Homo sapiens
53 Expression data from MCF7 wt xenografts Homo sapiens Homo sapiens
54 Comparison of Hepatocyte nuclear factor 4 alpha developmental and temporal knockout mice Mus musculus Mus musculus
55 Comparison of Hepatocyte nuclear factor 4 alpha developmental and temporal knockout mice Mus musculus Mus musculus
56 Tlx (nr2e1)-dependent gene expression in adult neural stem cells Mus musculus Mus musculus
57 KMT1E Mediated H3K9 Methylation Is Required for the Maintenance of Embryonic Stem Cells by Repressing Trophectoderm Differentiation Mus musculus Mus musculus
58 Expression data from tamoxifen treated and control injection treated Tg(αMHC-MerCreMer) and wild type mus musculus. Mus musculus Mus musculus
59 Expression data from tamoxifen treated and control injection treated Tg(αMHC-MerCreMer) and wild type mus musculus. Mus musculus Mus musculus
60 Expression data from tamoxifen treated and control injection treated Tg(αMHC-MerCreMer) and wild type mus musculus. Mus musculus Mus musculus
61 Expression data from primary MEF lacking either HDAC1, HDAC2 or both Mus musculus Mus musculus
62 Expression data from primary MEF lacking either HDAC1, HDAC2 or both Mus musculus Mus musculus
63 Tlx (nr2e1)-dependent gene expression in adult neural stem cells Mus musculus Mus musculus
64 Tlx (nr2e1)-dependent gene expression in adult neural stem cells Mus musculus Mus musculus
65 Tlx (nr2e1)-dependent gene expression in adult neural stem cells Mus musculus Mus musculus
66 Tlx (nr2e1)-dependent gene expression in adult neural stem cells Mus musculus Mus musculus

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.