Harmonizome 3.0

ALX homeobox 3

This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]

ALX homeobox 1

The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq, Jul 2008]

ALX homeobox 4

This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, cognitive disability, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009]

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the ALX 1405 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From DGIdb Drug Targets 2026

interacting proteins for the ALX 1405 drug from theDGIdb Drug Targets 2026 dataset.

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the piroxicam-1405 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term alx in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the ALX 1393 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the Alx-4 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the ALX-3 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From DGIdb Drug Targets 2026

interacting proteins for the ALX 1393 drug from theDGIdb Drug Targets 2026 dataset.