Harmonizome 3.0

dopamine beta-hydroxylase (dopamine beta-monooxygenase)

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]

DBH antisense RNA 1

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dbh in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for DBH from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the DBH gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the DBH-like monooxygenase protein 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From HuBMAP ASCT+B Annotations

biomarker genes for the Peripheral nervous system_CT4_superior cervical ganglion TH/DBH neuron cell type from the HuBMAP ASCT+B dataset.

From HuBMAP ASCT+B Annotations

biomarker genes for the Peripheral nervous system_CT4_middle cervical ganglion DBH neuron cell type from the HuBMAP ASCT+B dataset.

From HuBMAP ASCT+B Annotations

biomarker genes for the Peripheral nervous system_CT3_pelvic ganglion TH/DBH neuron cell type from the HuBMAP ASCT+B dataset.

From HuBMAP ASCT+B Augmented with RNA-seq Coexpression

biomarker genes for the Peripheral nervous system_CT3_pelvic ganglion TH/DBH neuron cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.

From HuBMAP ASCT+B Augmented with RNA-seq Coexpression

biomarker genes for the Peripheral nervous system_CT4_middle cervical ganglion DBH neuron cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.

From HuBMAP ASCT+B Augmented with RNA-seq Coexpression

biomarker genes for the Peripheral nervous system_CT4_superior cervical ganglion TH/DBH neuron cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.