Name

TARDBP Gene

TAR DNA binding protein

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

Ftld-Tdp, Tardbp-Related Gene Set

From DisGeNET Gene-Disease Associations

genes associated with the disease Ftld-Tdp, Tardbp-Related in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

ftld Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ftld in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

FTLD; ALS Gene Set

From PhosphoSitePlus Phosphosite-Disease Associations

proteins associated with the disease FTLD; ALS from the curated PhosphoSitePlus Phosphosite-Disease Associations dataset.

FTLD Gene Set

From PhosphoSitePlus Phosphosite-Disease Associations

proteins associated with the disease FTLD from the curated PhosphoSitePlus Phosphosite-Disease Associations dataset.

Alzheimer's disease; FTLD Gene Set

From PhosphoSitePlus Phosphosite-Disease Associations

proteins associated with the disease Alzheimer's disease; FTLD from the curated PhosphoSitePlus Phosphosite-Disease Associations dataset.

tardbp Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tardbp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TARDBP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TARDBP from the Pathway Commons Protein-Protein Interactions dataset.

TARDBP Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the TARDBP gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.