Name

H2AFY Gene

H2A histone family, member Y

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

h2afy Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term h2afy in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

H2AFY Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for H2AFY from the Pathway Commons Protein-Protein Interactions dataset.

Ubiquitin E3 ligase (H2AFY, SPOP, CUL3) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (H2AFY, SPOP, CUL3) protein complex from the CORUM Protein Complexes dataset.