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H2AFY GeneH2A histone family, member Y Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] |
h2afy Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term h2afy in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
H2AFY Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for H2AFY from the Pathway Commons Protein-Protein Interactions dataset. |
Ubiquitin E3 ligase (H2AFY, SPOP, CUL3) Gene Setproteins in the Ubiquitin E3 ligase (H2AFY, SPOP, CUL3) protein complex from the CORUM Protein Complexes dataset. |