Harmonizome 3.0

myelodysplastic syndrome 2 translocation associated

Located in extracellular space. [provided by Alliance of Genome Resources, Mar 2025]

high mobility group nucleosomal binding domain 2 pseudogene 31

high mobility group box 3 pseudogene 5

high mobility group nucleosomal binding domain 2 pseudogene 19

high mobility group nucleosomal binding domain 2 pseudogene 18

high mobility group nucleosomal binding domain 2 pseudogene 12

high mobility group nucleosomal binding domain 2 pseudogene 11

high mobility group nucleosomal binding domain 2 pseudogene10

high mobility group nucleosomal binding domain 2 pseudogene 17

high mobility group nucleosomal binding domain 2 pseudogene 16

high mobility group nucleosomal binding domain 2 pseudogene 15

high mobility group nucleosomal binding domain 2 pseudogene14

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide

The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

high mobility group nucleosome binding domain 1 pseudogene

high mobility group nucleosome binding domain 1 pseudogene 4

high mobility group nucleosome binding domain 1 pseudogene 5

high mobility group nucleosome binding domain 1 pseudogene 6

high mobility group nucleosome binding domain 1 pseudogene 7

high mobility group nucleosome binding domain 1 pseudogene 1

high mobility group nucleosome binding domain 1 pseudogene 2

high mobility group nucleosomal binding domain 2 pseudogene

high mobility group box 3

This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

high mobility group box 4

Predicted to enable DNA binding activity, bending. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

high mobility group nucleosomal binding domain 2 pseudogene 13

high mobility group box 1 pseudogene 12

high mobility group box 1 pseudogene 10

high mobility group box 1 pseudogene 16

high mobility group box 1 pseudogene 17

high mobility group box 1 pseudogene 36

high mobility group box 3 pseudogene 22

myopia 18 (high grade, autosomal recessive)

This locus was identified by linkage in one consanguineous Chinese family to lie between D14S984 and D14S999. [provided by RefSeq, Feb 2010]

myopia 11 (high grade, autosomal dominant)

high mobility group nucleosome binding domain 1 pseudogene 8

high mobility group nucleosome binding domain 1 pseudogene 3

high mobility group box 1 pseudogene 1

This gene may represent an evolving retropseudogene of the high-mobility group box 1 gene, which has multiple pseudogenes. This gene has an intact open reading frame, where the length of encoded protein is conserved, compared to the high-mobility group box 1 protein. However, due to the lack of conclusive evidence for specific transcription at this location, this locus is currently represented as a pseudogene. [provided by RefSeq, Jan 2010]

high mobility group box 1 pseudogene 3

high mobility group box 1 pseudogene 4

high mobility group box 1 pseudogene 5

high mobility group nucleosome binding domain 1 pseudogene 16

high mobility group nucleosome binding domain 1 pseudogene 17

high mobility group nucleosome binding domain 1 pseudogene 13

high mobility group nucleosome binding domain 1 pseudogene 10

high mobility group nucleosome binding domain 1 pseudogene 11

High density lipoprotein cholesterol level QTL 6

high density lipoprotein cholesterol level QTL 1

high mobility group nucleosome binding domain 1 pseudogene 33

high mobility group nucleosome binding domain 1 pseudogene 34

high mobility group box 3 pseudogene 32

high mobility group box 3 pseudogene 30

high mobility group box 3 pseudogene 31

high mobility group nucleosomal binding domain 2 pseudogene 33

high mobility group nucleosomal binding domain 2 pseudogene 32

high mobility group nucleosomal binding domain 2 pseudogene 35

high mobility group nucleosomal binding domain 2 pseudogene 34

high mobility group nucleosomal binding domain 2 pseudogene 37

high mobility group nucleosomal binding domain 2 pseudogene 36

high mobility group nucleosomal binding domain 2 pseudogene 39

high mobility group nucleosomal binding domain 2 pseudogene 38

high mobility group box 1 pseudogene 27

high mobility group box 1 pseudogene 24

high mobility group box 1 pseudogene 22

high mobility group box 1 pseudogene 29

high density lipoprotein binding protein

The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]

neurotensin receptor 1 (high affinity)

Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]

high mobility group box 1 pseudogene 18

high mobility group box 1 pseudogene 19

high mobility group box 1 pseudogene 11

high mobility group box 1 pseudogene 14

high mobility group box 1 pseudogene 15

high mobility group box 2

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

high mobility group box 1

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

high mobility group nucleosomal binding domain 3 pseudogene 1

high mobility group box 1 pseudogene 45

high mobility group AT-hook 2

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

high mobility group box 1 pseudogene 41

high mobility group box 1 pseudogene 40

high mobility group box 1 pseudogene 44

high mobility group box 1 pseudogene 47

high mobility group box 1 pseudogene 49

high mobility group box 1 pseudogene 48

high mobility group nucleosome binding domain 1 pseudogene 23

high mobility group nucleosome binding domain 1 pseudogene 22

high mobility group nucleosome binding domain 1 pseudogene 21

high mobility group nucleosome binding domain 1 pseudogene 27

high mobility group nucleosome binding domain 1 pseudogene 26

high mobility group nucleosome binding domain 1 pseudogene 25

high mobility group nucleosome binding domain 1 pseudogene 24

high mobility group nucleosome binding domain 1 pseudogene 29

high mobility group nucleosome binding domain 1 pseudogene 28

high mobility group box 3 pseudogene 2

high mobility group box 3 pseudogene 3

high mobility group box 3 pseudogene 1

high mobility group box 3 pseudogene 6

high mobility group box 3 pseudogene 7

high mobility group box 3 pseudogene 4

high mobility group box 3 pseudogene 8

high mobility group box 3 pseudogene 9

high mobility group 20A

Enables identical protein binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of neuron differentiation; negative regulation of protein sumoylation; and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

high mobility group 20B

Predicted to enable DNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of protein sumoylation; positive regulation of neuron differentiation; and skeletal muscle cell differentiation. Located in nuclear body. [provided by Alliance of Genome Resources, Mar 2025]

high mobility group AT-hook 1 pseudogene 4

high mobility group AT-hook 1 pseudogene 6

high mobility group box 1 pseudogene 34

high mobility group box 1 pseudogene 37

high mobility group box 1 pseudogene 30

high mobility group box 1 pseudogene 38

high mobility group box 1 pseudogene 39

high mobility group nucleosome binding domain 1 pseudogene 35

high mobility group box 1 pseudogene 35

high mobility group box 1 pseudogene 31

high mobility group box 1 pseudogene 32

high mobility group nucleosome binding domain 5

This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]

high mobility group nucleosomal binding domain 4

The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]

high mobility group nucleosomal binding domain 3

The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]

high mobility group nucleosomal binding domain 2

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

high mobility group nucleosome binding domain 1

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]

high mobility group AT-hook 1 pseudogene 8 (functional)

high mobility group AT-hook 1 pseudogene 5

high mobility group AT-hook 1 pseudogene 7

high mobility group AT-hook 1 pseudogene 1

high mobility group AT-hook 1 pseudogene 3

high mobility group AT-hook 1 pseudogene 2

high mobility group box 1 pseudogene 33

myopia 12 (high grade, autosomal dominant)

high mobility group AT-hook 1

This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

high mobility group nucleosomal binding domain 2 pseudogene 30

high mobility group nucleosomal binding domain 2 pseudogene 26

high mobility group nucleosomal binding domain 2 pseudogene 27

high mobility group nucleosomal binding domain 2 pseudogene 22

high mobility group nucleosomal binding domain 2 pseudogene 23

high mobility group nucleosomal binding domain 2 pseudogene 20

high mobility group nucleosomal binding domain 2 pseudogene 21

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

high mobility group nucleosomal binding domain 2 pseudogene 7

high mobility group nucleosomal binding domain 2 pseudogene 6

high mobility group nucleosomal binding domain 2 pseudogene 5

high mobility group nucleosomal binding domain 2 pseudogene 3

high mobility group nucleosomal binding domain 2 pseudogene 2

high mobility group nucleosomal binding domain 2 pseudogene 1

high mobility group nucleosomal binding domain 2 pseudogene 9

high mobility group box 1 pseudogene 26

high mobility group box 1 pseudogene 23

high mobility group box 1 pseudogene 28

high mobility group box 1 pseudogene 8

high mobility group box 1 pseudogene 9

Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene

The gene represents one of three related immunoglobulin gamma Fc receptor genes located on chromosome 1. This family member lacks the transmembrane and coiled-coiled domains found in other family members and is thought to be a pseudogene of Fc-gamma-receptor 1A. [provided by RefSeq, Apr 2009]

Fc fragment of IgG, high affinity Ib, receptor (CD64)

Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene likely encodes a non-functional protein that is not detectable at the cell surface and binds ligand with low affinity. [provided by RefSeq, Nov 2019]

Fc fragment of IgG, high affinity Ia, receptor (CD64)

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

high mobility group nucleosome binding domain 1 pseudogene 14

high mobility group nucleosome binding domain 1 pseudogene 15

high mobility group nucleosome binding domain 1 pseudogene 19

high mobility group box 1 pseudogene 25

high mobility group box 1 pseudogene 21

high mobility group box 1 pseudogene 20

high L-leucine transport

high mobility group box 1 pseudogene 43

high mobility group box 1 pseudogene 42

high mobility group box 1 pseudogene 46

high mobility group box 2 pseudogene 1

high mobility group nucleosome binding domain 1 pseudogene 18

high mobility group box 1 pseudogene 13

high mobility group box 3 pseudogene 25

high mobility group box 3 pseudogene 24

high mobility group box 3 pseudogene 27

high mobility group box 3 pseudogene 26

high mobility group box 3 pseudogene 20

high mobility group nucleosomal binding domain 2 pseudogene 28

high mobility group nucleosomal binding domain 2 pseudogene 29

high mobility group nucleosomal binding domain 2 pseudogene 25

high mobility group nucleosomal binding domain 2 pseudogene 24

high mobility group nucleosome binding domain 1 pseudogene 30

high mobility group nucleosome binding domain 1 pseudogene 31

high mobility group nucleosome binding domain 1 pseudogene 32

high mobility group nucleosome binding domain 1 pseudogene 36

high mobility group nucleosome binding domain 1 pseudogene 37

high mobility group nucleosome binding domain 1 pseudogene 38

thymocyte selection-associated high mobility group box

The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]

high mobility group box 1 pseudogene 6

high mobility group box 1 pseudogene 7

high mobility group nucleosomal binding domain 2 pseudogene 44

high mobility group nucleosomal binding domain 2 pseudogene 45

high mobility group nucleosomal binding domain 2 pseudogene 46

Predicted to enable chromatin binding activity. Predicted to be involved in chromatin organization. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

high mobility group nucleosomal binding domain 2 pseudogene 40

high mobility group nucleosomal binding domain 2 pseudogene 41

high mobility group nucleosomal binding domain 2 pseudogene 42

high mobility group nucleosomal binding domain 2 pseudogene 43

TOX high mobility group box family member 4

Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin and chromosome, telomeric region. Part of PTW/PP1 phosphatase complex. [provided by Alliance of Genome Resources, Mar 2025]

TOX high mobility group box family member 3

The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]

TOX high mobility group box family member 2

Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

Fc receptor, IgA, IgM, high affinity

Predicted to enable IgA binding activity; IgM binding activity; and transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

High density lipoprotein cholesterol level QTL 4

High density lipoprotein cholesterol level QTL 5

High density lipoprotein cholesterol level QTL on chromosome 8

high mobility group nucleosome binding domain 1 pseudogene 20

high mobility group box 3 pseudogene 14

high mobility group box 3 pseudogene 15

high mobility group box 3 pseudogene 16

high mobility group box 3 pseudogene 17

high mobility group box 3 pseudogene 10

high mobility group box 3 pseudogene 11

high mobility group box 3 pseudogene 12

high mobility group box 3 pseudogene 13

high mobility group box 3 pseudogene 18

high mobility group box 3 pseudogene 19

myopia 2 (high grade, autosomal dominant)

myopia 3 (high grade, autosomal dominant)

myopia 4 (high grade, autosomal dominant)

myopia 5 (high grade, autosomal dominant)

High density lipoprotein cholesterol, low serum, 3

high mobility group box 3 pseudogene 29

high mobility group box 3 pseudogene 28

high mobility group box 3 pseudogene 21

high mobility group box 3 pseudogene 23

high mobility group nucleosomal binding domain 2 pseudogene 4

high mobility group nucleosomal binding domain 2 pseudogene 8

high density lipoprotein binding protein pseudogene

solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

Enables L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity; and glutamate:sodium symporter activity. Involved in L-aspartate import across plasma membrane; L-glutamate import across plasma membrane; and neurotransmitter uptake. Located in intermediate filament cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

solute carrier family 1 (glial high affinity glutamate transporter), member 2

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]

solute carrier family 1 (glial high affinity glutamate transporter), member 3

This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]

TOX high mobility group box family member 4 pseudogene 1

cervical carcinoma high-expressed lncRNA 1