Name

LIMK1 Gene

LIM domain kinase 1

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

limk1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term limk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

LIMK1 Gene Set

From KEA Substrates of Kinases

substrates of the kinase LIMK1 from the curated KEA Substrates of Kinases dataset.

LIMK1 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for LIMK1 from the NURSA Protein-Protein Interactions dataset.

LIMK1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for LIMK1 from the Pathway Commons Protein-Protein Interactions dataset.

LIMK1 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase LIMK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

limk1mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term limk1mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

limk1regulated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term limk1regulated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

limk1cofilin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term limk1cofilin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

limk12 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term limk12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BL9709 (LIMK1) Gene Set

From NURSA Protein Complexes

proteins in the BL9709 (LIMK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.