Name

LIMK2 Gene

LIM domain kinase 2

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

limk2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term limk2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

LIMK2 Gene Set

From KEA Substrates of Kinases

substrates of the kinase LIMK2 from the curated KEA Substrates of Kinases dataset.

LIMK2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for LIMK2 from the Pathway Commons Protein-Protein Interactions dataset.

LIMK2 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase LIMK2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

limk2b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term limk2b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.