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LOXL4 Genelysyl oxidase-like 4 This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] |
loxl4 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term loxl4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
LOXL4 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for LOXL4 from the Pathway Commons Protein-Protein Interactions dataset. |
Interactions between LOXL4 and oxidative stress pathway Gene SetFrom WikiPathways Pathways 2024 proteins participating in the Interactions between LOXL4 and oxidative stress pathway pathway from the WikiPathways Pathways 2024 dataset. |