Name

NPPB Gene

natriuretic peptide B

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

nppb Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nppb in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NPPB Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the NPPB ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

NPPB Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NPPB from the Pathway Commons Protein-Protein Interactions dataset.