Harmonizome 3.0

cell division cycle 25A

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PAP associated domain containing 7

The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]

PAP associated domain containing 4

Enables poly(A) RNA polymerase activity. Involved in histone mRNA catabolic process; mRNA 3'-end processing; and negative regulation of miRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Predicted to be active in glutamatergic synapse; perforant pathway to dendrate granule cell synapse; and postsynapse. [provided by Alliance of Genome Resources, Mar 2025]

PAP associated domain containing 5

Enables guanylyltransferase activity; poly(A) RNA polymerase activity; and telomerase RNA binding activity. Involved in RNA metabolic process; carbohydrate homeostasis; and regulation of nucleobase-containing compound metabolic process. Located in cytosol; nucleolus; and plasma membrane. Part of TRAMP complex. [provided by Alliance of Genome Resources, Mar 2025]

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the PAP/25A-associated protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pap in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From DeepCoverMOA Drug Mechanisms of Action

proteins with high or low expression in PAP-1 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.