Harmonizome 3.0

protein tyrosine phosphatase, non-receptor type 3

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

From DEPOD Substrates of Phosphatases

substrates of the phosphatase PTPN3 from the curated DEPOD Substrates of Phosphatases dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ptpn3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PTPN3 from the Pathway Commons Protein-Protein Interactions dataset.

From HuBMAP Azimuth Cell Type Annotations

genes associated with the Human - Motor Cortex - Cluster - RORB+ PTPN3+ Layer 2-3 glutamatergic neuron cell type from the HuBMAP Azimuth Cell Type Annotations dataset.

From HuBMAP ASCT+B Annotations

biomarker genes for the Brain_CT2_Exc L2-3 RORB PTPN3 cell type from the HuBMAP ASCT+B dataset.

From HuBMAP ASCT+B Augmented with RNA-seq Coexpression

biomarker genes for the Brain_CT2_Exc L2-3 RORB PTPN3 cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.