Name

SI Gene

sucrase-isomaltase (alpha-glucosidase)

This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.[provided by RefSeq, Apr 2010]

SI Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SI from the Pathway Commons Protein-Protein Interactions dataset.

SI Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the SI gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.