Harmonizome 3.0

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

Enables NAD+-protein poly-ADP-ribosyltransferase activity and enzyme binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

Enables NAD+-protein poly-ADP-ribosyltransferase activity; histone binding activity; and zinc ion binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of chromosome organization. Acts upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Mar 2025]

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tankyrase-1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tankyrase in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Reactome Pathways 2014

proteins participating in the XAV939 inhibits tankyrase, stabilizing AXIN pathway from the Reactome Pathways dataset.

From DGIdb Drug Targets 2026

interacting proteins for the PARP/TANKYRASE INHIBITOR 2X-121 drug from theDGIdb Drug Targets 2026 dataset.