Harmonizome 3.0

Abdominal obesity-metabolic syndrome QTL1

abdominal obesity-metabolic syndrome QTL2

adipocyte associated metabolic related lncRNA 1

IMP (inosine 5'-monophosphate) dehydrogenase 1

The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 9

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 8

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 3

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 2

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 1

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 6

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 4

IMP (inosine 5'-monophosphate) dehydrogenase 2

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 11

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 10

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 7

IMP (inosine monophosphate) dehydrogenase 1 pseudogene 5