Harmonizome 3.0

VGF nerve growth factor inducible

This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

nerve growth factor receptor (TNFRSF16) associated protein 1

Enables identical protein binding activity. Predicted to be involved in negative regulation of protein ubiquitination and signal transduction. Predicted to act upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytosol. [provided by Alliance of Genome Resources, Mar 2025]

nerve growth factor (beta polypeptide)

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

Nerve growth factor, gamma subunit

nerve growth factor receptor

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

fibrous sheath CABYR-binding protein-like

fibrous sheath CABYR binding protein

Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of protein sumoylation. Predicted to be located in motile cilium. Predicted to be active in sperm fibrous sheath and sperm principal piece. [provided by Alliance of Genome Resources, Mar 2025]

fibrous sheath-interacting protein 2 pseudogene

fibrous sheath-interacting protein 2-like

fibrous sheath interacting protein 2

This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016]

fibrous sheath interacting protein 1

Predicted to act upstream of or within several processes, including axoneme assembly; homeostasis of number of cells within a tissue; and vesicle organization. Predicted to be active in acrosomal vesicle; nucleus; and sperm head. [provided by Alliance of Genome Resources, Mar 2025]

mitochondrial sheath formation associated

Predicted to be involved in sperm mitochondrial sheath assembly. Predicted to be located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Mar 2025]