MCF7_BD2K_LINCS_DCIC_COURSERA report

Categorized using metadata field pert_name

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Gene signatures

Signatures (153) and Custom Report Builder
Title Organism Platform
1 Breast adenocarcinoma MCF-7 cell line response to 27-Hydroxycholesterol and estradiol Homo sapiens Homo sapiens
2 Breast adenocarcinoma MCF-7 cell line response to 27-Hydroxycholesterol and estradiol Homo sapiens Homo sapiens
3 Estradiol effect on breast cancer cell line: time course Homo sapiens Homo sapiens
4 Leukemia inhibitory factor effect on Sin3a-silenced MCF7 breast cancer cell line Homo sapiens Homo sapiens
5 Estradiol effect on ERK1/ERK2-deficient MCF-7 breast adenocarcinoma cells: time course Homo sapiens Homo sapiens
6 Folic acid induces cell type-specific changes in the transcriptomes of breast cancer cell lines Homo sapiens Homo sapiens
7 PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer Homo sapiens Homo sapiens
8 PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer Homo sapiens Homo sapiens
9 PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer Homo sapiens Homo sapiens
10 PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer Homo sapiens Homo sapiens
11 PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer Homo sapiens Homo sapiens
12 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
13 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
14 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
15 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
16 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
17 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
18 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
19 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
20 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
21 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
22 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
23 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
24 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
25 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
26 Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis Homo sapiens Homo sapiens
27 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
28 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
29 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
30 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
31 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
32 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
33 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
34 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
35 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
36 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
37 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
38 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
39 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
40 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
41 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
42 6KR-EGFR expressing MCF7 following EGF or HRG stimulation Homo sapiens Homo sapiens
43 Over-expression of FGFR2b from a tetracycline-inducible expression vector Homo sapiens Homo sapiens
44 Over-expression of FGFR2b from a tetracycline-inducible expression vector Homo sapiens Homo sapiens
45 Over-expression of FGFR2b from a tetracycline-inducible expression vector Homo sapiens Homo sapiens
46 Over-expression of FGFR2b from a tetracycline-inducible expression vector Homo sapiens Homo sapiens
47 Over-expression of FGFR2b from a tetracycline-inducible expression vector Homo sapiens Homo sapiens
48 Over-expression of FGFR2b from a tetracycline-inducible expression vector Homo sapiens Homo sapiens
49 Over-expression of FGFR2b from a tetracycline-inducible expression vector Homo sapiens Homo sapiens
50 Over-expression of FGFR2b from a tetracycline-inducible expression vector Homo sapiens Homo sapiens
51 Gene expression profiles of MCF7 breast cancer cells following estrogen and anti-estrogen treatment. Homo sapiens Homo sapiens
52 Gene expression profiles of MCF7 breast cancer cells following estrogen and anti-estrogen treatment. Homo sapiens Homo sapiens
53 Gene expression profiles of MCF7 breast cancer cells following estrogen and anti-estrogen treatment. Homo sapiens Homo sapiens
54 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
55 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
56 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
57 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
58 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
59 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
60 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
61 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
62 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
63 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
64 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
65 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
66 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
67 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
68 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
69 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
70 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
71 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
72 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
73 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
74 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
75 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
76 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
77 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
78 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
79 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
80 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
81 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
82 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
83 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
84 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
85 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
86 Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines Homo sapiens Homo sapiens
87 Capturing drug responses by quantitative promoter activity profiling Homo sapiens Homo sapiens
88 Capturing drug responses by quantitative promoter activity profiling Homo sapiens Homo sapiens
89 Capturing drug responses by quantitative promoter activity profiling Homo sapiens Homo sapiens
90 Gene expression profiles of MCF7 with with the following NR ligands: estradiol/E2 (ERα agonist), AM580 (RARA agonist), CD437 (RARG agonist), ATRA (RARA/RARG agonist), GW0742 (PPARD agonist), R5020 (PGR agonist), and dexamethasone (GR/NR3C1 agonist). Homo sapiens Homo sapiens
91 Gene expression profiles of MCF7 with with the following NR ligands: estradiol/E2 (ERα agonist), AM580 (RARA agonist), CD437 (RARG agonist), ATRA (RARA/RARG agonist), GW0742 (PPARD agonist), R5020 (PGR agonist), and dexamethasone (GR/NR3C1 agonist). Homo sapiens Homo sapiens
92 Prolactin-inducible Stat5a-mediated and Stat5b-mediated gene profiles Homo sapiens Homo sapiens
93 Prolactin-inducible Stat5a-mediated and Stat5b-mediated gene profiles Homo sapiens Homo sapiens
94 Expression data from treatment of actinomycin D and triptolide on MCF7 cells Homo sapiens Homo sapiens
95 Expression data from treatment of actinomycin D and triptolide on MCF7 cells Homo sapiens Homo sapiens
96 Expression data from treatment of actinomycin D and triptolide on MCF7 cells Homo sapiens Homo sapiens
97 Expression data from treatment of actinomycin D and triptolide on MCF7 cells Homo sapiens Homo sapiens
98 Expression data from treatment of actinomycin D and triptolide on MCF7 cells Homo sapiens Homo sapiens
99 Expression data from treatment of actinomycin D and triptolide on MCF7 cells Homo sapiens Homo sapiens
100 Expression data from MCF7 tumor xenografts treated with either single agent BMS754807, or Tamoxifen or Letrozole alone; or Tamoxifen or Letrozole in combination with BMS754807 for 28 days Homo sapiens Homo sapiens
101 Expression data from MCF7 tumor xenografts treated with either single agent BMS754807, or Tamoxifen or Letrozole alone; or Tamoxifen or Letrozole in combination with BMS754807 for 28 days Homo sapiens Homo sapiens
102 Expression data from MCF7 tumor xenografts treated with either single agent BMS754807, or Tamoxifen or Letrozole alone; or Tamoxifen or Letrozole in combination with BMS754807 for 28 days Homo sapiens Homo sapiens
103 The genomic analysis of the interaction between the lactic acidosis and hypoxia response Homo sapiens Homo sapiens
104 The genomic analysis of the interaction between the lactic acidosis and hypoxia response Homo sapiens Homo sapiens
105 Resveratrol induces downregulation of DNA repair genes in MCF7 human breast cancer cells. Homo sapiens Homo sapiens
106 Resveratrol induces downregulation of DNA repair genes in MCF7 human breast cancer cells. Homo sapiens Homo sapiens
107 Genome-wide analysis of gene expression perturbed by Pontin shRNA in MCF7 subjected to normoxic and hypoxic conditions Homo sapiens Homo sapiens
108 Genome-wide analysis of gene expression perturbed by Pontin shRNA in MCF7 subjected to normoxic and hypoxic conditions Homo sapiens Homo sapiens
109 Genome-wide analysis of gene expression perturbed by Pontin shRNA in MCF7 subjected to normoxic and hypoxic conditions Homo sapiens Homo sapiens
110 Genome-wide analysis of gene expression perturbed by Pontin shRNA in MCF7 subjected to normoxic and hypoxic conditions Homo sapiens Homo sapiens
111 Genome-wide analysis of gene expression perturbed by Pontin shRNA in MCF7 subjected to normoxic and hypoxic conditions Homo sapiens Homo sapiens
112 Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes Homo sapiens Homo sapiens
113 Estrogen Coordinates Translation and Transcription Revealing a Role for NRSF in Human Breast Cancer Cells Homo sapiens Homo sapiens
114 Estrogen Coordinates Translation and Transcription Revealing a Role for NRSF in Human Breast Cancer Cells Homo sapiens Homo sapiens
115 Estrogen Coordinates Translation and Transcription Revealing a Role for NRSF in Human Breast Cancer Cells Homo sapiens Homo sapiens
116 Genome-wide analysis of gene expression perturbed by reptin shRNA in MCF7 subjected to normoxic and hypoxic conditions Homo sapiens Homo sapiens
117 Genome-wide analysis of gene expression perturbed by reptin shRNA in MCF7 subjected to normoxic and hypoxic conditions Homo sapiens Homo sapiens
118 Gene expression profiles of MCF7 with CARM1 knocked down Homo sapiens Homo sapiens
119 Gene expression profiles of MCF7 with CARM1 knocked down Homo sapiens Homo sapiens
120 Gene expression profile of NR2E3 in MCF7 cells Homo sapiens Homo sapiens
121 Gene expression profile of NR2E3 in MCF7 cells Homo sapiens Homo sapiens
122 The gene expression response of MCF7 and MDAMB231 to glutamine deprivation Homo sapiens Homo sapiens
123 Unique signatures of estrogen independent growth of MCF-7 cells in low-estrogen versus complete estrogen depravation Homo sapiens Homo sapiens
124 Unique signatures of estrogen independent growth of MCF-7 cells in low-estrogen versus complete estrogen depravation Homo sapiens Homo sapiens
125 Unique signatures of estrogen independent growth of MCF-7 cells in low-estrogen versus complete estrogen depravation Homo sapiens Homo sapiens
126 Unique signatures of estrogen independent growth of MCF-7 cells in low-estrogen versus complete estrogen depravation Homo sapiens Homo sapiens
127 Expression data from Control and Six1 expressing MCF7 derived xenograft tumors Homo sapiens Homo sapiens
128 Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer Homo sapiens Homo sapiens
129 Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer Homo sapiens Homo sapiens
130 Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer Homo sapiens Homo sapiens
131 Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer Homo sapiens Homo sapiens
132 Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer Homo sapiens Homo sapiens
133 Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer Homo sapiens Homo sapiens
134 Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer Homo sapiens Homo sapiens
135 Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer Homo sapiens Homo sapiens
136 Microarray analysis of MCF7 cells treated with NSC 59687 (Oxyphenisatin Acetate) Homo sapiens Homo sapiens
137 Cyclin D1 determines estrogen dependent signaling in human breast cancer cell line MCF7 Homo sapiens Homo sapiens
138 Gene expression profiles of mammary epithelial and breast cancer cells following fever range hyperthermia Homo sapiens Homo sapiens
139 PLK1 signaling coopereates with estrogen receptor-dependent gene transcription. Homo sapiens Homo sapiens
140 Transcriptome and translatome profiling of MCF7 vector cells after p53 activation Homo sapiens Homo sapiens
141 Transcriptome and translatome profiling of MCF7 vector cells after p53 activation Homo sapiens Homo sapiens
142 Transcriptome and translatome profiling of MCF7 vector cells after p53 activation Homo sapiens Homo sapiens
143 Transcriptome and translatome profiling of MCF7 vector cells after p53 activation Homo sapiens Homo sapiens
144 Transcriptome and translatome profiling of MCF7 vector cells after p53 activation Homo sapiens Homo sapiens
145 Transcriptome and translatome profiling of MCF7 vector cells after p53 activation Homo sapiens Homo sapiens
146 Gene expression profiles of MCF7 breast cancer cells following estrogen and anti-estrogen treatment. Homo sapiens Homo sapiens
147 Gene expression profiles of MCF7 breast cancer cells following estrogen and anti-estrogen treatment. Homo sapiens Homo sapiens
148 Cimicifuga racemosa extract effect on breast cancer cell line MCF-7 Homo sapiens Homo sapiens
149 Cimicifuga racemosa extract effect on breast cancer cell line MCF-7 Homo sapiens Homo sapiens
150 Cimicifuga racemosa extract effect on breast cancer cell line MCF-7 Homo sapiens Homo sapiens
151 Activator protein-2gamma silencing effect on MCF-7 breast tumor cell line Homo sapiens Homo sapiens
152 Activator protein-2gamma silencing effect on MCF-7 breast tumor cell line Homo sapiens Homo sapiens
153 Activator protein-2gamma silencing effect on MCF-7 breast tumor cell line Homo sapiens Homo sapiens

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.