Harmonizome 3.0

adrenoceptor beta 1

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Sep 2019]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term adrb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ADRB1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the ADRB1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CORUM Protein Complexes

proteins in the beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PRKAC-AKAP5-ADRB1 complex protein complex from the CORUM Protein Complexes dataset.