Harmonizome 3.0

M-phase phosphoprotein 9

Involved in negative regulation of cilium assembly. Located in Golgi apparatus; centriole; and centrosome. Implicated in multiple sclerosis. [provided by Alliance of Genome Resources, Mar 2025]

M-phase phosphoprotein 8

Enables chromatin binding activity; histone reader activity; and methylated histone binding activity. Involved in negative regulation of gene expression via chromosomal CpG island methylation and transposable element silencing by heterochromatin formation. Located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Part of nucleosome. [provided by Alliance of Genome Resources, Mar 2025]

M-phase phosphoprotein 6

Predicted to enable RNA binding activity. Involved in maturation of 5.8S rRNA. Located in cytosol and nuclear lumen. [provided by Alliance of Genome Resources, Mar 2025]

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) pseudogene

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) pseudogene

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) pseudogene

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) pseudogene

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)

This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]

stress-induced phosphoprotein 1

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 36

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 34

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 39

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B pseudogene 2

acidic (leucine-rich) nuclear phosphoprotein 32 family, member F

acidic (leucine-rich) nuclear phosphoprotein 32 family, member D

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

Enables histone binding activity; histone chaperone activity; and protein folding chaperone. Predicted to be involved in regulation of apoptotic process. Located in nucleus. Part of Swr1 complex. [provided by Alliance of Genome Resources, Mar 2025]

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B

Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including nucleosome assembly; positive regulation of cysteine-type endopeptidase activity; and positive regulation of protein export from nucleus. Located in cytoplasm; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

acidic (leucine-rich) nuclear phosphoprotein 32 family, member C

Predicted to enable histone binding activity. Predicted to be involved in nucleocytoplasmic transport and regulation of apoptotic process. Predicted to be active in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

Enables RNA binding activity. Involved in nucleocytoplasmic transport. Located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]

Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) pseudogene 1

cAMP-regulated phosphoprotein 19 pseudogene

cAMP-regulated phosphoprotein, 19kDa

The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]

M-phase phosphoprotein 6 pseudogene

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B pseudogene 1

golgi phosphoprotein 3-like

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008]

acidic (leucine-rich) nuclear phosphoprotein 32 family, member A pseudogene 1

src kinase associated phosphoprotein 2

The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

src kinase associated phosphoprotein 1

This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) pseudogene

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 50

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 51

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 52

vasodilator-stimulated phosphoprotein-like

chromosome alignment-maintaining phosphoprotein 1-like

nucleolar and coiled-body phosphoprotein 1

Enables molecular function inhibitor activity; protein heterodimerization activity; and protein-macromolecule adaptor activity. Involved in neural crest cell development; neural crest formation; and regulation of translation. Acts upstream of or within axonogenesis and regulation of synaptic plasticity. Located in fibrillar center. [provided by Alliance of Genome Resources, Mar 2025]

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 40

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 47

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 45

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 29

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 28

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 21

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 20

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 23

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 22

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 25

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 24

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 27

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 26

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 8

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 9

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 6

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 7

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 5

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 2

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 3

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 1

secreted phosphoprotein 1

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

secreted phosphoprotein 2, 24kDa

This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008]

cAMP-regulated phosphoprotein, 21kDa

This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

cAMP-regulated phosphoprotein, 19kDa pseudogene

nucleolar and coiled-body phosphoprotein 1 pseudogene

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 32

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 31

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 38

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 37

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 35

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 33

chromosome alignment maintaining phosphoprotein 1

This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with an autosomal dominant form of intellectual disability. [provided by RefSeq, Jul 2017]

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 43

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 44

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 49

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 48

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 41

dentin matrix acidic phosphoprotein 1

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

nucleolar and coiled-body phosphoprotein 1 pseudogene

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 42

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 46

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) pseudogene

stress-induced phosphoprotein 1 pseudogene 1

stress-induced phosphoprotein 1 pseudogene 2

stress-induced phosphoprotein 1 pseudogene 3

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 18

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 19

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 14

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 17

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 10

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 11

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 12

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 13

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) pseudogene

E2F-associated phosphoprotein

This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

golgi phosphoprotein 3 (coat-protein)

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) pseudogene

nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 4

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B pseudogene 3

vasodilator-stimulated phosphoprotein

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

M-phase phosphoprotein 8 pseudogene

phosphoprotein enriched in astrocytes 15

This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

odontogenesis associated phosphoprotein

Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene is thought to encode an extracellular matrix acidic phosphoprotein that has a function in enamel mineralization during amelogenesis. Mutations in this gene are associated with recessive hypomineralized amelogenesis imperfecta. [provided by RefSeq, Oct 2012]

secretory calcium-binding phosphoprotein proline-glutamine rich 1