Harmonizome 3.0

BMX non-receptor tyrosine kinase

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bmx in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase BMX from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for BMX from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase BMX from the curated PhosphoSitePlus Substrates of Kinases dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the BMX gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cytoplasmic tyrosine-protein kinase BMX protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein Complexes

proteins in the EPI-1594-1 (BMX) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From DGIdb Drug Targets 2026

interacting proteins for the BMX-IN-1 drug from theDGIdb Drug Targets 2026 dataset.