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CEP170 Genecentrosomal protein 170kDa The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
cep170 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term cep170 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
CEP170 Gene SetFrom NURSA Protein-Protein Interactions interacting proteins for CEP170 from the NURSA Protein-Protein Interactions dataset. |
CEP170 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for CEP170 from the Pathway Commons Protein-Protein Interactions dataset. |
CEP170 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the CEP170 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
CEP170 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the CEP170 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
CEP170, C-terminal Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the CEP170, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
BL4464 (CEP170) Gene Setproteins in the BL4464 (CEP170) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset. |