Harmonizome 3.0

cytochrome P450, family 2, subfamily C, polypeptide 8

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp2c8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CYP2C8 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CYP2C8 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Drug Metabolism, Altered, Cyp2C8-Related in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.