Harmonizome 3.0

E2F transcription factor 7

Enables DNA-binding transcription repressor activity; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of transcription by RNA polymerase II; and sprouting angiogenesis. Located in nuclear speck. [provided by Alliance of Genome Resources, Mar 2025]

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the E2F7-22180533-HELA-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets 2022

target genes of the E2F7-22180533-HELA-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets

target genes of the E2F7 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for E2F7 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the E2F7 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the Perturb_7854_KD_CCNF/E2F7/E2F8_SRP212181 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations

genes differentially expressed following the Perturb_11201_KO_Rb1/E2f7/E2f8_SRP315748 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the E2F7 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the E2F7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.